Peyronie’s Disease: Signs & Symptoms

Only 1-3% of men have been diagnosed with Peyronie’s
disease, but the numbers are potentially higher. This condition most often
affects men from the ages of 40-70, but it is not uncommon for it to affect 30 year olds.

Peyronie’s is characterized by the development of fibrous scar
tissue (plaque) on the tunica albuginea (lining) of the corpus cavernosum. It is often related to a penis injury, which ruptures the blood vessels causing increased swelling and bleeding. If a blockage occurs, due to the swelling, a formation of a clot is inevitable, then the immune cells will become totally trapped. An immune response is in order to combat the abnormality and a scar is eventually formed. While most cases show improvement, within a
year, other cases have been known to progress. In these cases, the scar (benign) will
harden and become more apparent, until the penis begins to exhibit a curvature, during
Over time, the male may begin to experience pain, during an erection and erectile dysfunction. An autoimmune disease may be linked to this disorder, which is an abnormal reaction, within the body, where the immune system attacks its own cells and organs.

Signs & Symptoms

Many men will attempt to ignore the signs and symptoms of Peyronie’s, until their sexual relationship becomes affected, due to pain and erectile dysfunction.

  • Hard lumps on the penis, but found more often near the front and sides
  • Partial erection
  • Penis may shorten in size and become more narrow
  • Painful erection
  • Curved penis
  • Emotional symptoms are also common including anxiety and depression.


The victim may be referred to a urologist (male reproductive and urinary tract specialists), in order to get a more clear and precise diagnosis. A thorough physical exam is vital for the diagnosis process.

  • Ultrasound
  • X-rays

While these diagnostic tests are not required to form an explanation of the signs and symptoms, they can detect scar tissue, which is a characteristic of Peyronie’s.


  • Interferon (Intron-A, Rebetron) is a protein secreted by the immune system. The medicine can assist in the breakdown of the fibrous scar.
  • Vitamin E
  • Verapamil Injections (at the scar site)
  • Steroids Injections
  • Radiation aimed at the plaque

Surgery may be prescribed in more severe cases, where other treatments were ineffective.

Things To Do

Smoking and increased alcohol consumption are noted to making the symptoms worse, so it vital for your health and to receive relief from this condition that you consider smoking and alcohol cessation. Exercising can help your mental capacity, as well as your overall health condition.

Avoid vigorous (forceful) sexual  activity to reduce risk of penis injury.

To view the anatomy of the male reproductive system please click here.